Dr Ghaith Aljayyoussi

Post Doctoral Research Associate

Ghaith Aljayyoussi currently leads the Pharmacokinetic/Pharmacodynamic modelling activities at the Anti-Wolbachia consortium in LSTM which is funded by the Bill and Melinda Gates Foundation. Additionally, Ghaith leads activities that would determine safe and efficacious clinical dosing regimens in clinical studies in the fields of Tuberculosis and Malaria therapy. 

Ghaith earned his PhD in 2013 from Cardiff University in Wales where he studied the use of cannabinoid based drugs for the treatment of Crohn’s disease and ulcerative colitis whilst minimising their (adverse) psychoactive effects.

Ghaith has a keen interest in the philosophy of science and the relationship between art, literature and science and is one of the organisers of the LSTM seminar series in the department of Tropical Biology at LSTM. 

Publications

  • O’Neil, et al. A tetraoxane-based antimalarial drug candidate that overcomes PfKelch 13-dependent artemisinin resistance. Accepted for Publication, Nature Communications

    Aljayyoussi, G., et al. “Pharmacokinetic-Pharmacodynamic modelling of intracellular Mycobacterium tuberculosis growth and kill rates is predictive of clinical treatment duration.” In press, Scientific Reports

    Aljayyoussi, G. et al. “Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis.” Scientific reports 7, 210, doi:10.1038/s41598-017-00322-5 (2017).

    Torok, M.E, Aljayyoussi, G. (Corresponding Author) “Suboptimal Exposure to Anti-TB Drugs in a TBM/HIV+ Population is not Related to Anti-retroviral Therapy.” Clinical pharmacology and therapeutics, doi:10.1002/cpt.646 (2017).

    Aljayyoussi, G., et al. “OptiMal-PK: an internet-based, user-friendly interface for the mathematical-based design of optimized anti-malarial treatment regimens.” Malaria journal 15, 344, doi:10.1186/s12936-016-1401-8 (2016).

    Lestner, M., Groll, H., Aljayyoussi G. et al. “Population Pharmacokinetics of Liposomal Amphotericin B in Immunocompromised Children.” Antimicrobial agents and chemotherapy 60, 7340-7346, doi:10.1128/AAC.01427-16 (2016).

    Sharma, R., Aljayyoussi G., et al. Minocycline as a re-purposed anti-Wolbachia macrofilaricide: superiority compared with doxycycline regimens in a murine infection model of human lymphatic filariasis. Scientific reports 6, 23458, doi:10.1038/srep23458 (2016).

    Hong, W. D. et al. Rational Design, Synthesis and Biological Evaluation of Heterocyclic Quinolones Targeting the respiratory chain of Mycobacterium tuberculosis. Journal of medicinal chemistry, doi:10.1021/acs.jmedchem.6b01718 (2017).

    Al-Jayyoussi, G, et al. "Absorption of ipratropium and l-carnitine into the pulmonary circulation of the ex-vivo rat lung is driven by passive processes rather than active uptake by OCT/OCTN transporters." International journal of pharmaceutics 496.2 (2015): 834-841.

    Williams, N, Aljayyoussi, G. et al. "An ex vivo investigation into the transurothelial permeability and bladder wall distribution of the nonsteroidal anti-inflammatory ketorolac." Molecular pharmaceutics 11.3 (2014): 673-682.

    Al‐Jayyoussi, G, et al. "Selectivity in the impact of P‐glycoprotein upon pulmonary absorption of airway‐dosed substrates: A study in ex vivo lung models using chemical inhibition and genetic knockout." Journal of pharmaceutical sciences 102.9 (2013): 3382-3394

    Aljayyoussi, G. and Gumbleton, M., “A novel cost-effective approach for the efficient radiolabeling of dendritic macromolecules with a β-emitting radiotracer.” Tetrahedron Letters 54.9 (2013): 1045-1048.

    Matthews, Ian P., Aljayyoussi, G.  et al. "Maximal extent of translocation of single-walled carbon nanotubes from lung airways of the rat." Environmental toxicology and pharmacology 35.3 (2013): 461-464.

    Campbell, L, Aljayyoussi, G. et al. "Caveolin-1 in renal cell carcinoma promotes tumour cell invasion, and in co-operation with pERK predicts metastases in patients with clinically confined disease." Journal of translational medicine 11 (2013): 255.

    Smith, MW, Al-Jayyoussi, G. and Gumbleton, M. "Peptide sequences mediating tropism to intact blood–brain barrier: An in vivo biodistribution study using phage display." Peptides 38.1 (2012): 172-180.

    Gumbleton, M, Aljayyoussi G., et al. "Spatial expression and functionality of drug transporters in the intact lung: objectives for further research." Advanced drug delivery reviews 63.1 (2011): 110-118.