Dr Krishanthi Subramaniam

Post Doctoral Research Assistant

Krishanthi Subramaniam received her PhD in Microbiology and Immunology from the Albert Einstein College of Medicine in New York in 2009. Her work focused on understanding the immunological parameters that dictate protection in HIV-associated cryptococcal disease. She remained at Albert Einstein and completed her first post-doctoral fellowship (2009-2012) in the laboratory of Dr. Johanna Daily where she evaluated host-pathogen interactions in the HIV-malaria co-infection model. She has conducted clinical projects in Uganda and Rwanda. She joined the Vector Biology Department in October 2012 as a post-doctoral research assistant in Martin Donnelly’s group and serves as a technical consultant on a WHO/Gates project assessing the impact of insecticide resistance on various epidemiological factors. Presently, she works in Alvaro Acosta-Serrano’s group in the Department of Parasitology developing novel diagnostics for screening other parasitic diseases, cutaneous and visceral leishmaniasis.

Teaching

Krishanthi has taught undergraduate biology and physiology courses at the Stern College for Women in New York. She also teaches on several LSTM modules including Trop 719 (Parasite Epidemiology and Control, Trop 974 (HIV in resource limited settings), and Trop 739 (Immunology of tropical diseases).

Research

Her current research is focused on infections caused by the parasites of the genus Leishmania. Specifically she is interested in using her immunology expertise to develop new diagnostics that can be used to screen for cutaneous and visceral leishmaniasis among infected populations. 

Publications

  • Selected publications

    Al-Salem W, Pigott DM, Subramaniam K, Haines LR, Kelly-Hope L, Molyneux DH, Hay SI, Acosta-Serrano A. (2016) ‘Cutaneous leishmaniasis and the conflict in Syria’ Emerging Infect Dis. 22(5): 931-933.

    Ochomo E, Subramaniam K, Kemei B, Rippon E, Bayoh N, Kamau L, Atieli F, Vulule J, Ouma C, Gimnig J, Donnelly M, and Mbogo C. (2015) Presence of the knockdown resistance mutation, Vgsc-1014F in Anopheles gambiae and Anopheles arabiensis in western Kenya. Parasites and Vectors: 8(1):616.

    Ngufor C, N’Guessan R, Fagbohoun J, Subramaniam K, Odjo A, Akogbeto M, Weetman D, and Rowland M. (2015). Insecticide resistance profile of Anopheles gambiae s.l. from a Phase II field station in Cove, Southern Benin: implications for the evaluation of novel vector control products. Malaria J: 14(1):464.

    Kleinschmidt I, Mnzava AP, Kafy HT, Mbogo C, Bashir A, Bigoga J, Adechoubou A, Raghavendra K, Knox TB, Malik EM, Nkuni ZJ, Bayoh N, Ochomo E, Fondjo E, Kouambeng C, Awono-Ambene HP, Etang J, Akogbeto M, Bhatt R, Swain DK, Kinyari T, Njagi K, Muthami L, Subramaniam K, Bradley J, West P, Massougbodji A, Oke-Sopoh M, Hounto A, Elmardi K, Valecha N, Kamau L, Mathenge E, and Donnelly MJ. (2015) Design of a study to determine the impact of insecticide resistance on malaria vector control: a multi-country investigation. Malaria Journal: 14(282).

    Subramaniam K, Skinner J, Ivan E, Mutimura E, Kim R, Feintuch C, Portugal S, Anastos K, Crompton P, Daily J. (2015) HIV-malaria co-infection is associated with atypical memory B cell expansion and a reduced antibody response to a broad array of Plasmodium falciparum antigens in Rwandan adults. PLOS One: 10(4).

    Subramaniam K, Spaulding E, Ivan E, Mutimura E, Kim R, Liu X, Dong C, Feintuch C, Zhang X, Anastos K, Lauvau G and Daily J. (2015) The T cell inhibitory molecule Butyrophilin-Like 2 is upregulated in mild Plasmodium falciparum infection and is protective during experimental cerebral malaria. Journal of Infectious Disease.

    Datta, K and Subramaniam, K. (2014) Host defense against cryptococcal disease: is there a role for B cells and antibody-mediated immunity. Current Fungal Infection Reports.

    Subramaniam K, Plank R, Lin N, Goldman-Yassen A, Ivan E, Becerril C, Kemal K, Heo M, Keller M, Mutimura E, Anastos K, Daily J. (2014) Plasmodium falciparum infection does not affect HIV viral load in co-infected Rwandan adults. Open Forum Infectious Disease: 1(2).

    Ochomo E, Bayoh N, Kamau L, Atieli F, Vulule J, Ouma C, Ombok M, Njagi K, Soti D, Mathenge E, Muthami L, Kinyari T, Subramaniam K, Donnelly MJ, Kleinschmidt I, Mbogo C. (2014) Pyrethroid susceptibility of malaria vectors in four districts of western Kenya. Parasites and Vectors: 7(310).

    Subramaniam K, Datta K, Marks M, Pirofski LA. (2010) The Absence of Serum IgM Enhances the Susceptibility of Mice to Pulmonary Challenge with Cryptococcus neoformans. Journal of Immunology: 184(10): 5755-67.

    Subramaniam K, Datta K, Marks M, Pirofski LA. (2010) Improved survival of mice deficient in secretory IgM following infection systemic infection with Cryptococcus neoformans. Infection and Immunity: 78(1): 441-52.

    Subramaniam K, Metzger B, Hanau L, Guh A, Rucker L, Badri S, Pirofski, LA. (2009) IgM (+) memory B cell expression predicts HIV-associated disease cryptococcosis status. Journal Infectious Disease: 200(2): 244-51.

    Subramaniam K, French N, Pirofski, LA. (2005) Cryptococcus neoformans - reactive and total immunoglobulin profiles of human immunodeficiency virus-infected and uninfected Ugandans. Clin Diagn Lab Immunol: 12(10): 1168-76.

    Maitta RW, Datta K, Chang Q, Luo RX, Witover B, Subramaniam K, Pirofski, LA. (2004) Protective and non-protective human immunoglobulin M monoclonal antibodies to Cryptococcus neoformans glucuronoxylomannan manifest different specificities and gene use profiles. Infection and Immunity: 72(8): 4810-8.

    Subramaniam K, Segal R, Lyles RH, Rodriguez-Barradas MC, Pirofski, LA. (2003) Qualitative change in antibody responses of human immunodeficiency virus-infected individuals to pneumococcal capsular polysaccharide vaccination associated with highly active antiretroviral therapy. Journal Infectious Disease: 187(5): 758-68.