Respiratory infections

Respiratory infections affect the young, the old, the poor and the vulnerable world-wide.  Our research targets the best methods of reducing susceptibility to infection, improving prevention and optimising treatment.

Chronic respiratory disease follows infection and makes future infection more likely.  We study the prevalence, causes, prevention and treatment of chronic lung disease.

In the wards and clinics

We understand that both the high incidence of respiratory infection and the increasing prevalence of non-communicable diseases are common to Low and Middle Income Countries (LMIC) and the UK.  There are important differences and similarities that allow mutually beneficial projects.

In the UK, we can:

  • Study new treatments for severe infection
  • Plan a role for early assisted discharge in pneumonia (HomeFIRST) in a setting with complex cases
  • Trial clinical interventions for asthma in a setting with high prevalence
  • Gain support from NHS clinical expertise and National Institute for Health Research resources such as the Clinical Research Network
  • Test innovative technology of global relevance
  • Support the training of junior doctors on the clinical academic track from academic foundation training throughAcademic Clinical Fellowship to Academic Clinical Lecturer posts.

In Malawi, we can:

  • Discover correlates of poor outcome in pneumonia
  • Study smoke prevention to avoid pneumonia in children and adults
  • Measure the development of chronic lung disease
  • Transfer best practice where applicable from UK to Malawi
  • Support training of junior doctors and researchers.

In the laboratory

We have extensive expertise in mucosal microbiology and immunology. We have state of the art laboratory facilities at LSTM in our Centre for Tropical and Infectious Disease (CTID)  and close collaboration with the Butantan Institute in Brazil and the Malawi-Liverpool-Wellcome programme in Blantyre, Malawi.

Our research strength is dependent on our excellent collaborations with the Royal Liverpool University Hospital, University Hospital Aintree, Liverpool Heart and Chest Hospital, the University of Liverpool and the NIHR, particularly the North West Coast CRN.

Respiratory Research Newsletter. Issue 1 2015