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Clinical Diagnostic Parasitology Laboratory
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Dr Alison Isaacs

Post Doctoral Research Assistant

Areas of interest

Host-pathogen interactions, insecticide resistance of Anopheles gambiae

Background

Alison Isaacs obtained a BSc in biology from Tufts University in 2006 and a PhD in Biomedical Sciences from the University of California Irvine in 2011.  Her thesis project aimed to create a genetically-modified mosquito that does not transmit the human malaria parasite Plasmodium falciparum.  As a Pasteur Cantarini fellow, she continued to investigate host-parasite interactions and mosquito population genetics at the Pasteur Institute in Paris.  She is currently working as a post-doctoral research assistant with Dr. Martin Donnelly in the Vector Group.

Research

My current research focus is identifying and characterizing insecticide resistance mechanisms in Anopheles gambiaemosquitoes from Eastern Uganda.  Furthermore, I aim to study the relationships between insecticide resistance, mosquito fitness, and P. falciparum population genetics.

Selected publications

  • Selected publications

    Isaacs AT, Jasinskiene N, Tretiakov M, Thiery I, Zettor A, Bourgouin C, & James AA.  Transgenic Anopheles stephensi coexpressing single-chain antibodies resist Plasmodium falciparum development. (2012) Proc Natl Acad Sci U S A 109, E1922.

    Franz AW, Jasinskiene N, Sanchez-Vargas I, Isaacs AT, Smith MR, Khoo CC, Heersink MS, James AA, & Olson KE.  Comparison of transgene expression in Aedes aegypti generated by mariner Mos1 transposition and PhiC31 site-directed recombination. (2011) Insect Mol Biol 20(5):587-598.

    Isaacs AT, Li F, Jasinskiene N, Chen X, Nirmala X, Marinotti O, Vinetz JM, & James AA.  Engineered resistance to Plasmodium falciparum development in transgenic Anopheles stephensi. (2011) PLoS Pathog 7(4):e1002017.

    Amenya DA, Bonizzoni M, Isaacs AT, Jasinskiene N, Chen H, Marinotti O, Yan G, & James AA.  Comparative fitness assessment of Anopheles stephensi transgenic lines receptive to site-specific integration. (2010) Insect Mol Biol 19(2):263-269.

    Wiley CD, Matundan HH, Duselis AR, Isaacs AT, & Vrana PB.  Patterns of hybrid loss of imprinting reveal tissue- and cluster-specific regulation. (2008) PLoS One 3(10):e3572.