New malaria control products: investigating mosquito insecticide interactions to improve malaria control

 

The Innovative Vector Control Consortium (IVCC) and industry partners are producing new insecticides to create the next generation of malaria control products www.ivcc.com to combat resistance. This project will investigate how these insecticides interact with mosquitoes in order to inform and help develop better strategies to reduce the risk of insecticide resistance development with deployment of these new insecticides.

Where does the project lie on the Translational Pathway?

T1 – Basic Research

Expected Outputs

1, Publications in specialist (biochemical, insect) and general journals e.g. JBC, Biochem J, PNAS, Curr Biol, IBMB,

2. Pilot data for funding applications e.g. BBSRC and Wellcome Trust

3. Development of new IP, tools and paradigms to counteract insecticide resistance 

Skills Required

 

Degree in biological or chemical discipline. Interest in vector biology and control.

 

Key Publications associated with this project

Yunta, C., Grisales, N., Nász, S., Hemmings, K., Pignatelli, P., Voice, M., Ranson, H., Paine, M.J.I., (2016) Pyriproxyfen is metabolized by P450s associated with pyrethroid resistance in An. gambiae. Insect Biochem. Mol. Biol. 78, 50–57. doi:10.1016/j.ibmb.2016.09.001

Ismail, H., O’Neill, P., Hong, D.,  Finn, R.D., Henderson, C.J. Wright, A. T., Cravatt, B. F., Hemingway, J., and Paine, M. J. I. (2013) Pyrethroid Activity-Based Probes for Profiling Cytochrome P450 Activities Associated with Insecticide Interactions Proc National Acad Sci. USA. Nov 18th early edition. doi 10.1073/pnas.1320185110

Edi, C. V., Djogbenou, L., Jenkins, A. M., Regna, K., Muskavitch, M. A., Poupardin, R., Jones, C. M., Essandoh, J., Ketoh, G. K., Paine, M. J., Koudou, B. G., Donnelly, M. J., Ranson, H., and Weetman, D. (2014) CYP6 P450 Enzymes and ACE-1 Duplication Produce Extreme and Multiple Insecticide Resistance in the Malaria Mosquito Anopheles gambiae. PLoS genetics 10, e1004236

Bradley J. Stevenson , Jaclyn Bibby , Patricia Pignatelli , Sant Muangnoicharoen , Paul M. O’Neill , Lu-Yun Lian, Pie Müller, Dimitra Nikou , Andrew Steven , Janet Hemingway , Michael J. Sutcliffe , Mark J. I. Paine  (2011) Cytochrome P450 6M2 from the malaria vector Anopheles gambiae metabolizes pyrethroids: sequential metabolism of deltamethrin revealed.  Insect Biochem Mol Biol.  41 492 – 50

David J.P, Ismail H.M, Chandor-Proust A, Paine M.J.I (2013) Role of cytochrome P450s in insecticide resistance: impact on the control of mosquito-borne diseases and use of insecticides on Earth. Philos Trans R Soc Lond B Biol Sci 368: 20120429. (Top 10 most cited in 2013)

LSTM Themes and Topics – Key Words

Malaria and other vector borne diseases