Professor Feiko ter Kuile

Chair in Tropical Epidemiology

Professor ter Kuile is a clinical epidemiologist who trained in medicine at the Academic Medical Centre of the University of Amsterdam. He previously worked on the Thai-Burmese border (1988-1994), where he was based at the Shoklo Malaria Research Unit as part of collaboration between the University of Oxford, the University of Amsterdam, and the Thai Mahidol University. This was followed by an 8-year period (1995-2003) with the Malaria Branch of the Centers for Disease Control and Prevention (CDC), firstly the KEMRI-CDC field station in Kisumu, Western Kenya (1995-2001), then as a senior medical epidemiologist in Atlanta, GA, USA (2001-2003). He joined LSTM as senior clinical lecturer in 2003 and since 2008 is Professor of Tropical Epidemiology, heading the malaria epidemiology section in the department of Clinical Sciences and LSTM’s malaria research collaboration with KEMRI’s Centre for Global Health Research and CDC’s malaria branch in western Kenya.

Teaching

Lectures and small group teaching on malaria epidemiology on the postgraduate Masters and diploma courses at LSTM.

Research

His main research interest is the epidemiology of malaria and the evaluation of new interventions for the for the control of malaria in children and pregnant women. He currently also heads the Malaria in Pregnancy Consortium, a network of 47 research institutions worldwide conducting research on the treatment and prevention of malaria in pregnancy.

Students

He currently supervises 6 Phd students and 2 MSc students

Other relevant expertise, professional memberships

•  Member of several Data Safety Monitoring Boards;

•  Regular ad hoc advisor to several of WHO’s Evidence Review Groups (ERG) for malaria

•  Chair, Executive Committee, Malaria in Pregnancy Consortium;

•  Chair management committee, IMPROVE Consortium malaria in pregnancy 

Current Projects

EDCTP and DFID/MRC/Wellcome Trust                           
ter Kuile (PI) 2016-2020 
Role: Chief Investigator
IPTp with dihydroartemisinin-piperaquine and azithromycin for malaria, sexually transmitted and reproductive tract infections in pregnancy in high sulphadoxine-pyrimethamine resistance areas in Kenya, Malawi and Tanzania (IMPROVE)

CDC Atlanta USA                                                                        
ter Kuile (PI) 2010-2015
Role: Principal Investigator

Cooperative agreement with the Malaria Branch, Centers for Disease Control and Prevention (CDC), Atlanta, GA

Globvac, Research Council Norway                         
Roberstad (grant holder)        2015-2019
Role: Chief Investigator
Multi-site trial investigating post-discharge malaria chemoprevention trial for the post-discharge management of severe anaemia in children in Uganda and Kenya (PMC trial)

MACEPA, PATH, Seattle                                                                   
ter Kuile (PI)    2011-2016
Role: Principal Investigator
Development of research on malaria transmission reduction and elimination in western Kenya

JGHT, DFID/MRC/Wellcome Trust  
ter Kuile (PI)    2011-2017
Role: Chief Investigator
Intermittent screening and treatment or intermittent preventive therapy for control of malaria in pregnancy in Indonesia (STOPMIP Indonesia)

Publications

  • Selected recent publications:

    Gutman J, Kovacs S, Dorsey G, Stergachis A, Ter Kuile FO, 2017. Safety, tolerability, and efficacy of repeated doses of dihydroartemisinin-piperaquine for prevention and treatment of malaria: a systematic review and meta-analysis. Lancet Infect Dis 17: 184-193.

    Williams JE, Cairns M, Njie F, Laryea Quaye S, Awine T, Oduro A, Tagbor H, Bojang K, Magnussen P, Ter Kuile FO, Woukeu A, Milligan P, Chandramohan D, Greenwood B, 2016. The Performance of a Rapid Diagnostic Test in Detecting Malaria Infection in Pregnant Women and the Impact of Missed Infections. Clin Infect Dis 62: 837-44.

    Smit MR, Ochomo E, Aljayyoussi G, Kwambai T, Abong'o B, Bayoh N, Gimnig J, Samuels A, Desai M, Phillips-Howard PA, Kariuki S, Wang D, Ward S, Ter Kuile FO, 2016. Efficacy and Safety of High-Dose Ivermectin for Reducing Malaria Transmission (IVERMAL): Protocol for a Double-Blind, Randomized, Placebo-Controlled, Dose-Finding Trial in Western Kenya. JMIR Res Protoc 5: e213.

    Madanitsa M, Kalilani L, Mwapasa V, van Eijk AM, Khairallah C, Ali D, Pace C, Smedley J, Thwai KL, Levitt B, Wang D, Kang'ombe A, Faragher B, Taylor SM, Meshnick S, Ter Kuile FO, 2016. Scheduled Intermittent Screening with Rapid Diagnostic Tests and Treatment with Dihydroartemisinin-Piperaquine versus Intermittent Preventive Therapy with Sulfadoxine-Pyrimethamine for Malaria in Pregnancy in Malawi: An Open-Label Randomized Controlled Trial. PLoS Med 13: e1002124.

    Almond D, Madanitsa M, Mwapasa V, Kalilani-Phiri L, Webster J, Ter Kuile F, Paintain L, 2016. Provider and user acceptability of intermittent screening and treatment for the control of malaria in pregnancy in Malawi. Malar J 15: 574.

    Kovacs SD, van Eijk AM, Sevene E, Dellicour S, Weiss NS, Emerson S, Steketee R, Ter Kuile FO, Stergachis A, 2016. The Safety of Artemisinin Derivatives for the Treatment of Malaria in the 2nd or 3rd Trimester of Pregnancy: A Systematic Review and Meta-Analysis. PLoS One 11: e0164963.

    Hill J, Kuile FO, 2016. Dihydroartemisinin-piperaquine holds promise as an option for malaria prevention in pregnancy. Evid Based Med.

    Desai M, Gutman J, Taylor SM, Wiegand RE, Khairallah C, Kayentao K, Ouma P, Coulibaly SO, Kalilani L, Mace KE, Arinaitwe E, Mathanga DP, Doumbo O, Otieno K, Edgar D, Chaluluka E, Kamuliwo M, Ades V, Skarbinski J, Shi YP, Magnussen P, Meshnick S, Ter Kuile FO, 2016. Impact of Sulfadoxine-Pyrimethamine Resistance on Effectiveness of Intermittent Preventive Therapy for Malaria in Pregnancy at Clearing Infections and Preventing Low Birth Weight. Clin Infect Dis 62: 323-33.

    Dellicour S, Aol G, Ouma P, Yan N, Bigogo G, Hamel MJ, Burton DC, Oneko M, Breiman RF, Slutsker L, Feikin D, Kariuki S, Odhiambo F, Calip G, Stergachis A, Laserson KF, Ter Kuile FO, Desai M, 2016. Weekly miscarriage rates in a community-based prospective cohort study in rural western Kenya. BMJ Open 6: e011088.

    Burger RJ, van Eijk AM, Bussink M, Hill J, Ter Kuile FO, 2016. Artemisinin-Based Combination Therapy Versus Quinine or Other Combinations for Treatment of Uncomplicated Plasmodium falciparum Malaria in the Second and Third Trimester of Pregnancy: A Systematic Review and Meta-Analysis. Open Forum Infect Dis 3: ofv170.