Professor Mike Lehane

Emeritus Chair in Molecular Entomology and Parasitology

After post-doctoral positions in the London School of Hygiene and Tropical Medicine I worked in the University of Wales, Bangor before joing the Liverpool School of Tropical Medicine in 2004.

Research

Tsetse Fly

Large scale field studies funded by the Bill and Melinda Gates Foundation. This work centres on the production of improved insecticide treated targets for tsetse control and their incorporation into large scale control operations. These field studies were carried out in collaboration with colleagues in Europe, Kenya, Chad, Uganda, Burkina Faso, Guinea, Cote d'Ivoire and Zimbabwe.

House spraying with insecticides for sandflies and mosquitoes

 

Fly traps

Triatomine bugs - the vectors of American trypanosomiasis - Chagas disease

 

 

 

Current Projects

Publications

  • Selected Publications

    Lehane, M.J. (2005) Biology of Blood-Sucking in Insects, Second Edition. Cambridge University Press. 321 pp.

    Aksoy, S., M. Berriman, N. Hall, M. Hattori, W. Hide, and M. J. Lehane (2005). A case for a Glossina genome project. Trends Parasitol 21:107-11.

    Vanlandingham, D.L., Chao Hong, Konstantin Tsetsarkin, Kate l. Mcelroy, Ann M. Powers, Roberto Nussenzveig, Michael Lehane and Stephen Higgs. (2005). Differential infectivities of O'nyong-nyong and Chikungunya virus isolates in Anopheles gambiae and Aedes aegypti mosquitoes. Am. J. Trop. Med. Hyg., 72(5), 2005, pp. 616-621

    Haines L. R., A. M. Jackson, J. D. Haddow, M. J. Lehane , J. M. Thomas, A. Y. Yamaguchi and T. W. Pearson (2005). Increased expression of unusual EP-repeat-containing proteins in the midgut of the tsetse fly (Glossina) after bacterial challenge. Insect Biochem. Mol. Biol. 35(5), 413-23

    Joanne V. Hamilton and Michael J. Lehane (2005) Tsetse midgut immunity - dige-esting for clues into african sleeping sickness. Outlooks on Pest Management. 16 (1), 19-22.

    Munks R.J.L., Sant-Anna M. Grail W., Igglesden T., Yoshiyama M., Lehane, S.M. and Lehane M.J. (2005) Antioxidant gene expression in the blood-feeding fly Glossina morsitans morsitans. Insect Molecular Biology. 14, 483-491

    Vanlandingham, D.L., Konstantin Tsetarkin, Chao Hong, Kimberly Klingler, McElroy, K, Michael J. Lehane, and Stephen Higgs. (2005). Development and characterization of a double subgenomic chikungunya virus infectious clone to expess heterologous genes in Aedes aegypti mosqutioes. Insect Biochemistry and Molecular Biology. 35, 1162-1170.

    Meredith, J.M., R. Munks, H. Hurd, P. Eggleston and M. J. Lehane. (2006) Multiple NF-κB and C/EBP binding sites are required for induced expression of mosquito defensins. Insect Molecular Biology. 15(4), 393-401.

    Vanlandingham, D.L., Tsetsarkin, K., Klingler, K.A., Hong, C., Mcelroy, C.L., Lehane, M.J. and Higgs, S. (2006). Determinants of vector specificity of o'nyong nyong and chikungunya viruses in Anopheles and Aedes mosquitoes.
    Am J Trop Med Hyg. 74(4), 663-9.

    R.N. Araujo, A. Santos, F.S. Pinto, N.F. Gontijo, M.J. Lehane and M.H. Pereira (2006) RNA interference of the salivary gland nitrophorin 2 in the triatomine bug Rhodnius prolixus (Hemiptera: Reduviidae) by dsRNA ingestion or injection. Insect Biochemistry and Molecular Biology. 36, 683-93

    Rod J. Dillon, Alister C Ivens; Carol Churcher; Nancy Holroyd; Michael A Quail; Matthew E Rogers; M Bento Soares; Maria F Bonaldo; Thomas L Casavant; Mike J Lehane; Paul A Bates. (2006) Analysis of ESTs from Lutzomyia longipalpis Sand Flies and their Contribution towards Understanding the Insect-Parasite Relationship. Genomics. 88, 831-840.

    Adriana Santos , José Marcos C. Ribeiro, Michael J. Lehane, Nelder Figueiredo Gontijo, Artur Botelho Veloso, Mauricio R.V. Sant'Anna, Ricardo Nascimento Araujo, Edmundo C. Grisard, Marcos Horácio Pereira. (2007) The sialotranscriptome of the blood-sucking bug Triatoma brasiliensis (Hemiptera, Triatominae). Insect Biochemistry and Molecular Biology. 37(7):702-12.

    R.N. Araujo, I.T.N. Campos, A.S. Tanaka, A. Santos, N.F. Gontijo, M.J. Lehane, M.H. Pereira. (2007). Brasiliensin: a novel intestinal thrombin inhibitor from Triatoma brasiliensis (Hemiptera: Reduviidae) with an important role in blood intake. International Journal for Parasitology. 37(12):1351-8.

    Roditi, I. and Lehane, M.J. (2008) Interactions between trypanosomes and tsetse flies. Current Opinion in Microbiology 11(4):345-5

    Meredith, J.M., H. Hurd, M. J. Lehane and P. Eggleston. (2008) The malaria vector mosquito Anopheles gambiae expresses a suite of larval-specific defensin genes. Insect Molecular Biology. 17(2): 103-112.

    Lehane, M.J., Gibson, W.C. and Lehane, S.M. (2008) Differential expression of fat body genes in Glossina morsitans morsitans following infection with Trypanosoma brucei brucei. International Journal for Parasitology. 38(1):93-101.

    Dyer, N.A., Lawton, S.P., Ravel, S., Choi, K.S., Lehane, M.J., Robinson, A.S., Okedi, L.M., Hall, M.J.R., Solano, P., Donnelly, M.J. (2008). Molecular phylogenetics of tsetse flies (Diptera: Glossinidae) based on mitochondrial (COI, 16S, ND2) and nuclear ribosomal DNA sequences, with an emphasis on the palpalis group. Molecular Phylogenetics and Evolution. 49: 227-239.

    Deirdre P. Walshe, Cher Pheng Ooi, Michael J. Lehane and Lee R. Haines (2009) The enemy within: Interactions between Tsetse, Trypanosomes and Symbionts. Advances in Insect Physiology. v. 37, 119-175.

    Deirdre P. Walshe, Stella Lehane, M.J. Lehane and Lee R. Haines. (2009) Prolonged gene knockdown in the tsetse fly Glossina by feeding double stranded RNA . Insect Molecular Biology. 18: 11-19

    Ricardo N Araujo, Adriana Soares, Rafaela M M Paim, Nelder F Gontijo, Michael J Lehane and Marcos H Pereira (2009)The role of salivary nitrophorins in the ingestion of blood by the triatomine bug Rhodnius prolixus(Reduviidae; Triatominae). Insect Biochemistry and Molecular Biology. 39: 83-9

    Lindh J.M., Torr S.J., Vale G.A. and Lehane M.J. (2009) Improving the cost-effectiveness of artificial visual baits for controlling the tsetse fly Glossina fuscipes fuscipes. Plos Neglected Tropical Diseases. Jul 7;3(7):e474 pp doi:10.1371/journal.pntd.0000474.

    Maurice O. Omolo, Ahmed Hassanali, Serge Mpiana, Johan Esterhuizen, Jenny Lindh, Mike J. Lehane, Philippe Solano, Jean Baptiste Rayaisse, Glyn A. Vale, Steve J. Torr, Inaki Tirados. (2009) Prospects for developing odour baits to control Glossina fuscipes spp., the major vector of human African trypanosomiasis. Plos Neglected Tropical Diseases. 3(5) e435 pp1-9.

    Ricardo N. Araujo, Marcos H. Pereira, Adriana C. Soares, Iancor D.C.A. Pereira, Lilelia Diotaiuti, Nelder F. Gontijo, Michael J. Lehane, Alessandra A. Guarneri (2009). Effect of intestinal erythrocyte agglutination on the feeding performance of Triatoma brasiliensis (Hemiptera: Reduviidae). Journal of Insect Physiology 55, 862-868.

    Rayaisse, J. B., I. Tirados, D. Kaba, S. Dewhirst, J. Logan, A. Diarrassouba, E. Salou, M. Omolo, P. Solano, M.J. Lehane, J. Pickett, G.A. Vale, S.J. Torr & J. Esterhuizen (2009) Prospects for the development of odour baits to control the tsetse flies Glossina tachinoides and G. palpalis s.l., vectors of trypanosomiasis in West Africa. Plos Neglected Tropical Diseases. Mar 16;4(3):e632.

    Renhu Liu, Stella Lehane, Xiaoli He, Mike Lehane, Christiane Hertz-Fowler, Matthew Berriman, John A. Pickett, Linda M. Field and Jing-Jiang Zhou (2009). Characterisations of odorant binding proteins in the tsetse fly Glossina morsitans morsitans. Cellular and Molecular Life Sciences. (doi:10.1007/s00018-009-0221-1)

    Deirdre P. Walshe,  Cher Pheng Ooi,  Michael J. Lehane and Lee R. Haines (2009) The enemy within: Interactions between Tsetse, Trypanosomes and Symbionts.  Advances in Insect Physiology. v. 37,  119-175.

    Haines, L, Lehane, S.M., Pearson, T.W. and Lehane, M.J. (2010) Tsetse EP Protein Protects the Fly Midgut from Trypanosome Establishment.   Plos Pathogens.  Mar 5;6(3):e1000793.