Deployment of new combination insecticidal bednets in Africa to combat pyrethroid resistance in malaria mosquitoes

Deployment of new combination insecticidal bednets in Africa to combat pyrethroid resistance in malaria mosquitoes.

Malaria prevention in Africa is dependent on Insecticide Treated Nets (ITNs) which prevented 500 million malaria cases from 2000-2015. 

However, until 2017, all insecticides used in ITNs were pyrethroids and LSTM’s research has highlighted the public health threat from pyrethroid resistance. 

Research Outputs

Barnes KG, Weedall GD, Ndula M, Irving H, Mzihalowa T, Hemingway J, Wondji CS. 2017. Genomic Footprints of Selective Sweeps from Metabolic Resistance to Pyrethroids in African Malaria Vectors Are Driven by Scale-up of Insecticide-Based Vector Control.PLoS Genet 13: e1006539.

Implications of insecticide resistance for malaria vector control with long-lasting insecticidal nets: a WHO-coordinated, prospective, international, observational cohort study. Lancet Infect Dis. 2018 Jun; 18(6): 640–649. doi: 10.1016/S1473-3099(18)30172-5

Churcher TS, Lissenden N, Griffin JT, Worrall E, Ranson H. 2016. The impact of pyrethroid resistance on the efficacy and effectiveness of bednets for malaria control in Africa. Elife 5.

Tiono AB, Ouédraogo A, Ouattara D, Bougouma EC, Coulibaly S, Diarra A, Faragher B, Guelbeogo Page 11 of 37 et al, Ranson H, Lindsay SW. Efficacy of Olyset Duo, a bednet containing pyriproxyfen and permethrin, versus a permethrin-only net against clinical malaria in an area with highly pyrethroid resistant vectors in rural Burkina Faso: a cluster-randomised controlled trial. Lancet. 2018 Aug 18;392(10147):569-580. PMID:30104047

GPD Murray, N Lissenden, J Jones, V Voloshin, KH Toé, E Sherrard-Smith, GM Foster, TS Churcher, JEA Parker, CE Towers, WM Guelbeogo, Sagnon N’Falé, H. Ranson, D. Towers, P. J. McCall.  Barrier bednets target malaria vectors and expand the range of usable insecticides. Nature Microbiology,5, 40–47 (2020).

Reducing Malaria Prevalence in Africa Through New Classes of Insecticide-Treated Nets

Widespread use of insecticide treated nets (ITNs) has dramatically reduced the incidence of malaria in Africa but resistance to pyrethroid insecticides in Anopheles mosquitoes is eroding their efficacy.

In this seminar LSTM Professor Hilary RansonProfessor Martin DonnellyProfessor Philip McCallDr David Weetman and Dr Gareth Lycett highlight how research from the Department of Vector Biology at LSTM on the mechanisms underpinning pyrethroid resistance, and the behavioural response of mosquitoes to ITNS has led to the development of new classes on ITNs mosquitoes.They will highlight how, by working in partnership with different sectors we have developed the evidence base for the public health value of these nets that has led to their widespread deployment across Africa to combat resistant mosquito populations.