Head of Department, Vector Biology Department, LSTM
Professor of Evolutionary Genetics, LSTM
Honorary Faculty Member, Malaria Programme, Wellcome Trust Sanger Institute
I trained at Girton College, Cambridge University and the Liverpool School of Tropical Medicine. I then spent two years in the laboratory of Dr Tovi Lehmann at the Centers for Disease Control and Prevention, Atlanta, on an American Society of Microbiology Fellowship. I re-joined the Department of Vector Biology in 2001.
A major area of interest is the evolution of insecticide resistance in the malaria mosquito Anopheles gambiae. We use a variety of approaches to identify and validate insecticide resistance associated loci.
Much of this work is conducted jointly with Dr David Weetman and team. A second research area is understanding the impact of insecticide resistance on malaria epidemiology ,through observational studies and randomized control trials.
Key external partnerships include:
1. Professor Dominic Kwiatkowski at the Wellcome Sanger Institute, through this collaboration we leverage the power of next-generation sequencing technologies to address aspects of the biology of Anopheles gambiae that impact upon the sustainable control of malaria.
2. Drs. Eric Ochomo (https://www.kemri.org/cghr-staff/#1571147896050-de94dc00-cfd2) and Ben Abong’o ( https://www.kemri.org/cghr-staff/#1580926897769-d285238f-ea32 ) at KEMRI, Kisumu. Together we work on a range of basic and translational science projects including vector control trials and machine learning approaches for identifying insecticide resistant variants in genomic and transcriptomic data sets.
3. Dr. Luigi Sedda, Lancaster University (https://www.lancaster.ac.uk/health-and-medicine/about-us/people/luigi-sedda). The development of spatially explicit sampling frameworks for vectors including adaptive sampling.
4. Drs. Catherine Moyes (https://www.bdi.ox.ac.uk/Team/catherine-moyes ) and Penny Hancock (https://www.bdi.ox.ac.uk/Team/penny-hancock) from the Big Data Institute, University of Oxford, lead a collaboration on geospatial modelling of insecticide resistance.
6. Dr Luc Djogbenou is a Professor and Wellcome Trust Fellow based at the Institut Régional de Santé Publique/University of Abomey-Calavi. His fellowship addresses the interaction between insecticide resistance and vectorial ability in Anopheles gambiae
Past PhD students
2019 Ben Abong’o, Research Scientist, KEMRI, Kisumu
2018 Paul Howell, Verily Life Sciences
2016 Kevin Opondo, VectorLink, Kisumu
2015 Chris Clarkson, Senior Staff Scientist, Wellcome Sanger Institute
2015 Fabricio Martins, Faculty Member Universidade Estadual da Paraíba
2015 Victor Asoala, Scientist Navrongo Health Research Centre
2014 Bilali Kabula, Scientist, National Institute of Medical Research, Tanzania
2013 Bruno Gomes, PDRA, Fiocruz, Brasil
2010 Sara Mitchell, Staff Scientist, Verily Life Sciences
2008 Amy Lynd, Senior PDRA LSTM
2008 Samuel Dadzie- Senior researcher Noguchi Institute for Medical Research, Ghana.
2007 Nadine Randle- PDRA, University of Liverpool
2005 Eveline Klinkenberg- Senior Epidemiologist KNCV Tuberculosis Foundation, The Netherlands
2005 Alexander Egyir-Yawson- Senior Lecturer, University of Cape Coast, Ghana