Title |
NIHR ref |
RLBUHT RD&I |
LSTM RD&I |
REC EudraCT |
Primary objective |
Funder |
Testing new strains in the EHPC Model Started 2017 |
5124 |
15-051 |
15/NW/0931 |
To establish experimental human carriage with a non-vaccine and 23F serotype pneumococcus. To determine the protective effect of carriage against reacquisition of carriage following inoculation with a different pneumococcal strain. |
MRC |
|
EHPC: Early and late nasal and tonsil cell responses during human pneumococcal colonisation Started 2017 |
18994 |
5414 |
16-068 |
To establish whether nasal and tonsil biopsies provide sufficient cell yield for measurement of cell populations |
MRC |
|
EHPC: Hand Wash Study Started 2017 |
|
N/A |
17-077 |
To evaluate if hand washing with antimicrobial soap affects hand to nose transmission of Streptococcus pneumoniae leading to nasal colonisation |
Pharma: Unilever |
|
EHPC: Hand to nose transmission of streptococcus pneumoniae in healthy participants – pilot study Started 2017 |
33503 |
5376 |
16-069 |
To determine the feasibility of Experimental Pneumococcal Carriage acquisition following pneumococcal transmission from hand to nostrils. |
MRC and Pharma: |
|
EHPC: The effect of asthma on immune response to Pneumococcus Started 2016 |
20857 |
5173 |
16-010 |
To determine the rate of EHPC acquisition in people with asthma To study the systemic and mucosal immune responses To determine the protective effect of carriage against reacquisition of carriage |
MRC |
|
EHPC: The effect of age on immune function |
20792 |
5174 |
15-053 |
Detection of S. pneumoniae by classical bacteria culture methods from one or more nasal wash sample in the first 14 days following initial pneumococcal challenge. |
MRC |