EHPC Current Clinical Trials

Title

NIHR ref

RLBUHT

RD&I

LSTM

RD&I

REC

EudraCT 
number:

Primary objective

Funder

Testing new strains in the EHPC Model

Started 2017

20815

5124

15-051

15/NW/0931

To establish experimental human carriage with a non-vaccine and 23F serotype pneumococcus.

To determine the protective effect of carriage against reacquisition of carriage following inoculation with a different pneumococcal strain.

MRC

EHPC: Early and late nasal and tonsil cell responses during human pneumococcal colonisation 

Started 2017

18994

5414

16-068

17/NW/0029

To establish whether nasal and tonsil biopsies provide sufficient cell yield for measurement of cell populations

MRC

EHPC: Hand Wash Study

Started 2017

N/A

17-077

17/NW/0658

To evaluate if hand washing with antimicrobial soap affects hand to nose transmission of Streptococcus pneumoniae leading to nasal colonisation

Pharma:

Unilever

EHPC:  Hand to nose transmission of streptococcus pneumoniae in healthy participants – pilot study

Started 2017

33503

5376

16-069

17/NW/0054

To determine the feasibility of Experimental Pneumococcal Carriage acquisition following pneumococcal transmission from hand to nostrils.

MRC

and

Pharma:

EHPC: The effect of asthma on immune response to Pneumococcus

Started 2016

20857

5173

16-010

16/NW/0124

To determine the rate of EHPC acquisition in people with asthma 

To study the systemic and mucosal immune responses

To determine the protective effect of carriage against reacquisition of carriage

MRC

EHPC: The effect of age on immune function

20792

5174

15-053

16/NW/0031

Detection of S. pneumoniae by classical bacteria culture methods from one or more nasal wash sample in the first 14 days following initial pneumococcal challenge.

MRC