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Dr Shaun Pennington

Lecturer in Infection and Immunity

Shaun was awarded a PhD in Infection and Immunity from the University of Liverpool in 2017. His interests lie in human immunity and the interplay between host and pathogen.

Research:

Shaun utilises controlled human infection as well as advanced ex vivo models for studies investigating disease pathogenesis and host immune defence. His activities support a broad translational research portfolio towards delivery of new vaccines and novel therapeutic strategies to the clinic.

Teaching

Shaun currently lectures and leads teaching tutorials on the topics of ‘Pharmacodynamics’ and the ‘Immunology of Tropical Disease’ at LSTM.

Shaun is a member of the Royal Society of Biology.

Recent publications: 

    Selected publications

    • Pennington SH, Pojar S, Mitsi E, Gritzfeld JF, Nikolaou E, Solórzano C, Owugha JT, Masood Q, Gordon MA, Wright AD, Collins AM, Miyaji EN, Gordon SB, Ferreira DM. Polysaccharide-Specific Memory B Cells Predict Protection against Experimental Human Pneumococcal Carriage. Am J Respir Crit Care Med. 2016 Dec 15;194(12):1523-1531. doi: 10.1164/rccm.201512-2467OC. PMID: 27403678; PMCID: PMC5215029.

      Pennington SH, Ferreira DM, Caamaño-Gutiérrez E, Reiné J, Hewitt C, Hyder-Wright AD, Gordon SB, Gordon MA. Nonspecific effects of oral vaccination with live-attenuated Salmonella Typhi strain Ty21a. Sci Adv. 2019 Feb 27;5(2):eaau6849. doi: 10.1126/sciadv.aau6849. PMID: 30820452; PMCID: PMC6392763.

      Jin C, Gibani MM, Pennington SH, Liu X, Ardrey A, Aljayyoussi G, Moore M, Angus B, Parry CM, Biagini GA, Feasey NA, Pollard AJ. Treatment responses to Azithromycin and Ciprofloxacin in uncomplicated Salmonella Typhi infection: A comparison of Clinical and Microbiological Data from a Controlled Human Infection Model. PLoS Negl Trop Dis. 2019 Dec 26;13(12):e0007955. doi: 10.1371/journal.pntd.0007955. PMID: 31877141; PMCID: PMC6948818.

      Sposito F, Pennington SH, David CAW, Duggan J, Northey S, Biagini GA, Liptrott NJ, Charras A, McNamara PS, Hedrich CM. Age-differential CD13 and interferon expression in airway epithelia affect SARS-CoV-2 infection - Effects of vitamin D. Mucosal Immunol. 2023 Sep 1:S1933-0219(23)00064-8. doi: 10.1016/j.mucimm.2023.08.002. Epub ahead of print. PMID: 37574128.

      Donnellan S, Pennington SH, Ruggiero A, Martinez-Rodriguez C, Pouget M, Thomas J, Ward SA, Pollakis G, Biagini GA, Paxton WA. A Quantitative Method for the Study of HIV-1 and Mycobacterium tuberculosis Coinfection. J Infect Dis. 2023 Mar 1;227(5):708-713. doi: 10.1093/infdis/jiac491. PMID: 36537213; PMCID: PMC9978310.