Dr Shaun Pennington

Senior Research Associate

Shaun was awarded a PhD in Infection and Immunity from the University of Liverpool in 2017. His interests lie in human immunity and the interplay between host and pathogen.

Shaun has utilised controlled human infection as well as several advanced in vitro models of infection to support vaccine development and inform the optimisation of novel therapeutic strategies targeting bacterial and viral pathogens.


Shaun is currently the laboratory lead for drug discovery at LSTM. His research is focused on the development and application of multi-organ, dynamic-flow systems for the study of host-pathogen interaction and for the assessment of vaccine and drug activity.


Shaun currently lectures and leads teaching tutorials on the topics of ‘Pharmacodynamics’ and the ‘Immunology of Tropical Disease’ at LSTM.

Shaun is a member of the Royal Society of Biology.

Selected publications

  • Jeffreys, Laura , Pennington, Shaun , Duggan, Jack, Caygill, Claire, Lopeman, Rose, Breen, Alastair, Jinks, Jessica, Ardrey, Alison, Donnellan, Samantha, Patterson, Ian , Hughes, Grant , Hong, David W, O'Neill, Paul M, Aljayyoussi, Ghaith, Owen, Andrew, Ward, Steve and Biagini, Giancarlo (2022) 'Remdesivir-ivermectin combination displays synergistic interaction with improved in vitro activity against SARS-CoV-2'. International Journal of Antimicrobial Agents, Vol 59, Issue 3, e106542.

    Jin, Celina, Gibani, Malick M, Pennington, Shaun. H , Liu, Xinxue, Ardrey, Alison, Aljayyoussi, Ghaith, Moore, Maria, Angus, Brian, Parry, Christopher, Biagini, Giancarlo , Feasey, Nicholas and Pollard, Andrew J (2019) 'Treatment responses to Azithromycin and Ciprofloxacin in uncomplicated Salmonella Typhi infection: A comparison of Clinical and Microbiological Data from a Controlled Human Infection Model'. PLoS Neglected Tropical Diseases, Vol 13, Issue 12, e0007955.

    Pennington, Shaun , Ferreira, Daniela , Caamaño-Gutiérrez, E, Reiné, Jesús, Hewitt, C, Hyder-Wright, Angela, Gordon, Stephen and Gordon, Melita (2019) 'Nonspecific effects of oral vaccination with live-attenuated Typhi strain Ty21a'. Science Advances, Vol 5, Issue 2, eaau6849.

    Pennington, Shaun , Pojar, Sherin , Mitsi, Elena, Gritzfeld, Jenna, Nikolaou, Elissavet, SolorzanoGonzalez, Carla, Owugha, Jessica, Masood, Qasim, Gordon, Melita, Wright, Angela, Collins, Andrea , Miyaji, Eliane N, Gordon, Stephen and Ferreira, Daniela (2016) 'Polysaccharide-specific memory B-cells predict protection against experimental human 1 pneumococcal carriage'. American Journal of Respiratory and Critical Care Medicine, Vol 194, Issue 12, pp. 1523-1531.

    Pennington, Shaun , Thompson, Ameeka, Wright, Adam, Ferreira, Daniela , Jambo, Kondwani , Wright, Angela, Faragher, Brian, Gilmour, Jill W., Gordon, Stephen and Gordon, Melita A. (2016) 'Oral typhoid vaccination with Ty21a generates Ty21a-responsive and heterologous influenza-responsive CD4+and CD8+T-cells at the human intestinal mucosa'. Journal of Infectious Disease, Vol 213, Issue 11, pp. 1809-1819. Item not available from this repository.