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Dr Shaun Pennington

Post-doctoral Research Associate

Shaun first graduated in 2010 with a BSc (Hons) in Biological Sciences from the University of Liverpool. Shaun returned to the University of Liverpool as a postgraduate student and graduated in 2011 with a MSc in Human Immunity. 

Shaun holds a PhD in Infection and Immunity from the University of Liverpool. The focus of his doctoral thesis was the assessment of the human immune response to oral vaccination with live-attenuated Salmonella Typhi.

Shaun’s immunological background has been applied for the study of host-pathogen interaction as well as for vaccine discovery and drug development

Shaun has been responsible for the management of the LSTM’s flow cytometry service and he currently manages the LSTM’s HG3 imaging facility.

Research:

Shaun’s research is currently focused on the development of in vitro models of typhoidal and non-typhoidal Salmonella infection for the study of bacterial pathogenesis and for use in the assessment of novel treatment strategies.

Recent publications: 

    Selected publications

    • Selected publications

      Collins, A. M. et al. First Human Challenge Testing of a Pneumococcal Vaccine. Double-Blind Randomized Controlled Trial. American journal of respiratory and critical care medicine 192, 853-858, doi:10.1164/rccm.201503-0542OC (2015).

      Glennie, S. et al. Modulation of nasopharyngeal innate defenses by viral coinfection predisposes individuals to experimental pneumococcal carriage. Mucosal Immunol, doi:10.1038/mi.2015.35 (2015).

      Morton, B., Pennington, S. H. & Gordon, S. B. Immunomodulatory adjuvant therapy in severe community-acquired pneumonia. Expert review of respiratory medicine 8, 587-596, doi:10.1586/17476348.2014.927736 (2014).

      Gritzfeld, J. F. et al. Experimental human pneumococcal carriage. Journal of visualized experiments : JoVE, doi:10.3791/50115 (2013).

      Ferreira, D. M. et al. Controlled human infection and rechallenge with Streptococcus pneumoniae reveals the protective efficacy of carriage in healthy adults. American journal of respiratory and critical care medicine 187, 855-864, doi:10.1164/rccm.201212-2277OC (2013).