Dr Tony Nolan

Senior Lecturer

1997 BSc at Imperial College: Applied Biology
2003 PhD at Imperial College: A transformation technology for mosquito vectors of malaria
2003-2008 Postdocs at University of Rome “la Sapienza” and University College London looking at genome defence mechanisms against genetic parasites and ageing.
2008-2018 Senior Research Fellow in the Target Malaria research consortium, leading research to develop gene drives for the control of the malarial mosquito.

Selected publications

  • Control of malaria-transmitting mosquitoes using gene drives T Nolan Philosophical Transactions of the Royal Society B (2021) Vol 367, Issue 1818

    Regulation of gene drive expression increases its invasive potential and mitigates resistance A Hammond, X Karlsson, I Morianou, K Kyrou, A Beaghton, M Gribble, N Kranjc, R Galizi, A Burt, A Crisanti, T Nolan PLoS Genetics (2021) 17(1): e1009321

    A male-biased sex-distorter gene drive for the human malaria vector Anopheles gambiae. Simoni A, Hammond AM, Beaghton AK, Galizi R, Taxiarchi C, Kyrou K, Meacci D, Gribble M, Morselli G, Burt A, Nolan T, Crisanti A. Nature Biotechnology 2020 May 11

    Toward the Definition of Efficacy and Safety Criteria for Advancing Gene Drive-Modified Mosquitoes to Field Testing. James SL, Marshall JM, Christophides GK, Okumu FO, Nolan T. Vector Borne Zoonotic Dis. 2020 Apr;20(4):237-251. Kyrou K, Hammond AM, Galizi R, Kranjc N, Burt A, Beaghton AK, Nolan T and Crisanti A

    A CRISPR-Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes Nature Biotechnology 2018, 36, pages1062–1066 A Hammond, K Kyrou, M Bruttini, A North, R Galizi, X Karlsson, F Carpi, R D’Aurizio, A Crisanti and T Nolan

    The dynamics of creation and selection of mutations resistant to a gene drive over multiple generations in the malaria mosquito PLoS Genetics 2017, Oct 9 A Hammond, R Galizi, K Kyrou, A Simoni, C Siniscalchi, D Katsanos, M Gribble, D Baker, E Marois, S Russell, A Burt, N Windbichler, A Crisanti and T Nolan.

    A CRISPR-based Gene Drive System Targeting Female Reproduction in the Malaria Mosquito. Nature Biotechnology 34,78–83 (2016)