An informal introduction to methods used throughout the school Learn about both fundamental and novel technologies from the experts.
Broaden your knowledge of tropical medicine and be inspired to try these methods in your own work!
See https://lstmed.sharepoint.com/mtmm(link is external) for more info and presentations from previous meetings
Dr. Grazia Camarda, Department of Parasitology
Plasmodium parasites: in vitro culture and their use in drug discovery assays
According to the WHO, malaria caused an estimate 438000 deaths in 2015. Plasmodium parasites from 5 different species are able to infect humans. Plasmodium falciparum and P. vivax account for most of the morbidity and, especially for P. falciparum, the mortality associated with the infection. Despite many efforts, we are still far from having a reliable vaccine, therefore the fight against malaria still relies on drugs, and drug resistance is of major concern, and vector control. To date, only P. falciparum can be efficiently grown in vitro, thus providing as with an extremely valuable tool to study the biology of the parasite and to identify new ways of therapeutic intervention. This presentation will describe the current protocols used to perform P. falciparum cultures and how they are used for drug discovery purposes.
Dr. Jennifer Lord, Department of Vector Biology
Using model-motivated data collection and data-driven models: examples from vector-borne disease research
Mathematical models have been used for decades to better understand drivers of pathogen transmission and predict the effects of control strategies. I will give a brief guide to different types of models- from a field-biologist's perspective- and outline how theoretical and empirical approaches are currently being used in unison in infectious disease research projects. To do this, I’ll draw from examples in the vector-borne disease literature and my own research on arboviruses and African trypanosomiasis, highlighting benefits of coupling models and data to understand the transmission ecology of vector-borne pathogens.