There are many issues which arise in assessing the effectiveness of antimalarial drugs. A person may have several malaria infections (clones) present at the time of treatment and still be liable to be bitten and re-infected.
For this reason, special attention is given to classifying the clone outcomes as cured, recrudesced (infections which never fully clear), new or ambiguous based on 3 genetic markers. The method used to incorporate new infections, once classified, is still an area for discussion. Some believe they should be removed from the analysis where as others think they should be included as successes, failures or censored. Results from work comparing the different methods of incorporating new infections using simulated data will be discussed.
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