Martin J Boeree, MD, Phd on behalf of the PanACEA consortium, Radboudumc, Nijmegen, the Netherlands
The current accepted treatment dose of rifampicin may be too low. The maximium tolerated dose has yet to be identified. We will contine the HR1 experiment with higher dosages with the next step being 50 mg/kg. Higher dosages seem to be well tolerated. Furthermore, the data suggest that 15 and 20 mg/kg are still on the lower side of the dose-response curve. 35mg/kg rifampicin reduced the time to culture conversion sifnificantly. Higher dosages of rifampicin may be an important component in future treatment-shortening regimens.