The epidemiology and etiology of tuberculosis with implications for vaccine development

Event 9 Apr 2015

Professor Nico Nagelkerke

Tuberculosis is one of the great scourges of mankind and until recently a major cause of death in Europe and America. In developing countries it still kills millions despite chemotherapy. Although Koch discovered the tubercle bacillus more than a century ago, the epidemiology of the disease is still poorly understood. Its greatest enigma is why tuberculous infections occasionally cause disease but mostly remain asymptomatic. Co-infection with HIV is the only known cause of progression from infection to disease, but most tuberculosis victims are HIV negative. In my book (2012) Courtesans and Consumption evidence is presented that there may be another virus that causes progression to disease; a virus that like HIV can be transmitted sexually and via blood contacts.

Nico Nagelkerke  is a widely published biostatistician and infectious disease epidemiologist. He has worked in the fields biostatistics, infectious disease modelling, and the epidemiology of HIV, tuberculosis, and other infectious diseases in several countries including Kenya, the United Arab Emirates, and his native country the Netherlands. Nagelkerke's R-square, a measure of explained variation for non-linear models is currently available in SPSS and other statistical packages. Until the end of 2013, he was professor of biostatistics with the United Arab Emirates University. He joins LSTM on May15th and looks forward to working as a Senior Biostatistician at MLW in Blantyre, Malawi.