Dr Linta Grigoraki

Post Doctoral Research Associate

I received a Diploma in Biology (2011) and a MSc in Molecular Biology and Biomedicine (2013) from the University of Crete. I did my PhD (2013-2017) in the field of Molecular entomology in the University of Crete and the Institute of Molecular Biology and Biotechnology (FORTH-IMBB, Heraklion).
My PhD thesis focused on the molecular characterisation of organophosphate resistance in the tiger mosquito Aedes albopictus.
In October 2017 I joined the Vector group in LSTM as a Post Doctoral Research Associate. 


The cuticle plays an important role in the physiology of mosquitoes and their response to insecticides. By being the outermost part of the body, the cuticle is the first barrier to the penetration of insecticides, while it also protects from water loss and influences chemical communication. Despite its importance in controlling key traits little is known about its formation. My research focuses on identifying genes that are involved in the synthesis of the  cuticle, in the major malaria vector An. gambiae, and studying how variations in these genes might affect traits, like insecticide resistance, that determine its fitness and vectorial capacity. 


Selected publications

  • Selected Publications

    Vontas J, Grigoraki L, Morgan J, Tsakireli D, Fuseini G, Segura L, et al. Rapid selection of a pyrethroid metabolic enzyme CYP9K1 by operational malaria control activities. P Natl Acad Sci USA. 2018;115(18):4619-24.

    Balabanidou V, Grigoraki L and Vontas J. (2018) Insect cuticle: a critical determinant of insecticide resistance. Current Opinion in Insect science (27) https://doi.org/10.1016/j.cois.2018.03.001

    Grigoraki L, Puggioli A, Mavridis K, Douris V, Monatanary M, Bellini R and Vontas J. (2017) Striking diflubenzuron resistance in Culex pipiens, the prime vector of West Nile Virus. Scientific Reports 15;7(1):11699. doi: 10.1038/s41598-017-12103-1.

    Grigoraki L, Pipini D, Labbé P, Chaskopoulou A, Weill M, and Vontas J. (2017). Carboxylesterase gene amplifications associated with insecticide resistance in Aedes albopictus: Geographical distribution and evolutionary origin. PLoS Neglected Tropical Diseases, 11(4), e0005533. http://doi.org/10.1371/journal.pntd.0005533

    Seixas G, Grigoraki L, Weetman D, Vicente J. L., Silva A. C., Pinto J., Sousa C. A. (2017). Insecticide resistance is mediated by multiple mechanisms in recently introduced Aedes aegypti from Madeira Island (Portugal). PLoS Neglected Tropical Diseases, 11(7), e0005799. http://doi.org/10.1371/journal.pntd.0005799

    Fotakis E.A., Chaskopoulou A, Grigoraki L, Tsiamantas A, Kounadi S, Georgiou L, and Vontas J. (2017). Analysis of population structure and insecticide resistance in mosquitoes of the genus Culex, Anopheles and Aedes from different environments of Greece with a history of mosquito borne disease transmission. Acta Tropica, 174. https://doi.org/10.1016/j.actatropica.2017.06.005

    Grigoraki L, Balabanidou V, Meristoudis C, Miridakis A, Ranson H, Swevers L, Vontas J (2016) Functional and immunohistochemical characterization of CCEae3a, a carboxylesterase associated with temephos resistance in the major arbovirus vectors Aedes aegypti and Ae. albopictus. Insect Biochem Mol Biol ;74:61-7. doi: 10.1016/j.ibmb.2016.05.007

    Grigoraki L, Balabanidou V, Pipini D, Strati F, Vontas J. (2016) Analysis of Insecticide Resistance in Mosquito Disease Vectors: From Molecular Mechanisms to Management Arthropod-borne Infectious Diseases and Arthropods as Disease Agents Nova Acta Leopoldina 411.

    Grigoraki L, Lagnel J, Kioulos I, Kampouraki A, Morou E, Labbé P, Weill M, Vontas J (2015) Transcriptome Profiling and Genetic Study Reveal Amplified Carboxylesterase Genes Implicated in Temephos Resistance, in the Asian Tiger Mosquito Aedes albopictus. PLoS Negl Trop Dis 9(5):e0003771. doi:10.1371/journal.pntd.0003771