Professor Mike Lehane

Emeritus Chair in Molecular Entomology and Parasitology

After post-doctoral positions in the London School of Hygiene and Tropical Medicine I worked in the University of Wales, Bangor before joing the Liverpool School of Tropical Medicine in 2004.


Tsetse Fly

Large scale field studies funded by the Bill and Melinda Gates Foundation. This work centres on the production of improved insecticide treated targets for tsetse control and their incorporation into large scale control operations. These field studies were carried out in collaboration with colleagues in Europe, Kenya, Chad, Uganda, Burkina Faso, Guinea, Cote d'Ivoire and Zimbabwe.

House spraying with insecticides for sandflies and mosquitoes


Fly traps

Triatomine bugs - the vectors of American trypanosomiasis - Chagas disease

Selected publications

  • International Glossina Genome Initiative (2014) Genome Sequence of the Tsetse Fly (Glossina morsitans): Vector of African Trypanosomiasis. Science  344 doi:10.1126/science.1249656.

    Rose C, Belmonte R, Armstrong SD, Molyneux G, Haines LR, Lehane MJ, Wastling J, Acosta-Serrano A.   (2014) An Investigation into the protein composition of the teneral Glossina morsitans morsitans peritrophic matrix.  PLOS Neglected Tropical Diseases.  24;8(4):e2691. doi: 10.1371/journal.pntd.0002691.

    Christoffels A, Masiga D, Berriman M, Lehane M, Touré Y, et al. (2014) International Glossina Genome Initiative 2004–2014: A Driver for Post-Genomic Era Research on the African Continent. PLoS Negl Trop Dis 8(8): e3024. doi:10.1371/journal.pntd.0003024

    Alexandra P.M. Shaw,  Inaki Tirados, Clement T.N. Mangwiro, Johan Esterhuizen, Michael J. Lehane, Stephen J. Torr, and Vanja Kovacic (2015) Costs of using ‘tiny targets’ to control Glossina fuscipes fuscipes, a vector of Gambiense sleeping sickness in Arua District of Uganda.  PLoS Negl Trop Dis 9.  e0003624

    Tirados I, Esterhuizen J, Kovacic V, Mangwiro TNC, Vale GA, et al. (2015) Tsetse Control and Gambian Sleeping Sickness; Implications for Control Strategy. PLoS Negl Trop Dis 9.  e0003822  

    Fabrice Courtin, Mamadou Camara, Jean-Baptiste Rayaisse, Moise Kagbadouno, Emilie Dama, Oumou Camara, Ibrahima S Traoré, Jérémi Rouamba, Moana Peylhard, Martin B Somda, Mamadou Leno, Mike J Lehane Steve J Torr, Philippe Solano, Vincent Jamonneau, Bruno Bucheton (2015) Reducing human-tsetse contact significantly enhances the efficacy of sleeping sickness active screening campaigns: a promising result in the context of elimination.  PLoS NTD  9.   e0003727  

    Glyn A. Vale, John W. Hargrove, Philippe Solano, Fabrice Courtin, Jean-Baptiste Rayaisse,  Michael J. Lehane, Johan Esterhuizen, Inaki Tirados, and Stephen J. Torr    (2015)    Optimal Strategies for Controlling Riverine Tsetse Flies Using Targets: a Modelling Study  PLoS NTD 9. e0003615  

    Ooi C-P, Haines LR, Southern DM, Lehane MJ, Acosta-Serrano A (2015) Tsetse GmmSRPN10 Has Anti-complement Activity and Is Important for Successful Establishment of Trypanosome Infections in the Fly Midgut. PLoS Negl Trop Dis 9.   e3448  

    David P. Alt, Jennifer H. Wilson-Welder, Darrell O. Bayles, Caroline Cameron, Ben Adler, Dieter M. Bulach, Torsten Seemann Michael J. Lehane, Lee R. Haines, Alistair C. Darby, Neil Hall, Alan D. Radford, Richard L. Zuernera  (2015)   Complete Genome Sequence of Leptospira interrogans Serovar Bratislava, Strain PigK151   Genome Announcements  3(3):e00678-15. doi:10.1128/genomeA.00678-15.

    Kovacic V, Tirados I, Esterhuizen J, Mangwiro CTN, Lehane MJ, et al. (2016) We Remember ... Elders' Memories and Perceptions of Sleeping Sickness Control Interventions in West Nile, Uganda. PLoS Negl Trop Dis 10.  e0004745  

    Mantilla BS, Marchese L, Casas-Sanchez A, Dyer NA, Ejeh N, et al. (2017) Proline Metabolism is Essential for Trypanosoma brucei brucei Survival in the Tsetse Vector. PLoS Pathog 13(1): e1006158.

    Rayaisse, J-B.; Mahamat, H. M.; Peka, M.; et al. (2017)  Adding tsetse control to medical activities contributes to decreasing transmission of sleeping sickness in the Mandoul focus (Chad). TROPICAL MEDICINE & INTERNATIONAL HEALTH   Volume: 22   Special Issue: SI   Supplement: 1   Pages: 51-51   Meeting Abstract: 4S1.5  

    Tirados, Inaki; Mpembele, Fabrice; Bessell, Paul; et al.  (2018) LARGE-SCALE USE OF INSECTICIDE-IMPREGNATED 'TINY TARGETS' TO CONTROL TSETSE FLIES IN THE DEMOCRATIC REPUBLIC OF CONGO.  Conference: 67th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTHM) Location: New Orleans, LA Date: OCT 28-NOV 01, 2018   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE   Volume: 99   Issue: 4   Supplement: S   Pages: 652-652   Meeting Abstract: 2073

    Attardo et al. (2019) Comparative genomic analysis of six Glossina genomes, vectors of African trypanosomes.  Genome Biology 20:187

    Trypa-NO! contributes to the elimination of gambiense human African trypanosomiasis by combining tsetse control with “screen, diagnose and treat” using innovative tools and strategies    Ndung’u, Joseph Mathu, Boulangé, Alain, Picado, Albert, Mugenyi, Albert, Mortensen, Allan, Hope, Andrew, Mollo, Brahim Guihini, Bucheton, Bruno, Wamboga, Charles, Waiswa, Charles, Kaba, Dramane, Matovu, Enock, Courtin, Fabrice, Garrod, Gala, Gimonneau, Geoffrey, Bingham, Georgina V., Hassane, Hassane Mahamat, Tirados, Inaki, Saldanha, Isabel, Kabore, Jacques, Rayaisse, Jean-Baptiste, Bart, Jean-Mathieu, Lingley, Jessica, Esterhuizen, Johan, Longbottom, Joshua, Pulford, Justin, Kouakou, Lingue, Sanogo, Lassina, Cunningham, Lucas, Camara, Mamadou, Koffi, Mathurin, Stanton, Michelle, Lehane, Mike, Kagbadouno, Moise Saa, Camara, Oumou, Bessell, Paul, Mallaye, Peka, Solano, Philippe, Selby, Richard, Dunkley, Sophie, Torr, Steve, Biéler, Sylvain, Lejon, Veerle, Jamonneau, Vincent, Yoni, Wilfried and Katz, Zachary (2020) 'Trypa-NO! contributes to the elimination of gambiense human African trypanosomiasis by combining tsetse control with “screen, diagnose and treat” using innovative tools and strategies'. PLoS Neglected Tropical Diseases, Vol 14, Issue 11, e0008738.

     Tirados, Inaki, Hope, Andrew, Selby, Richard, Mpembele, Fabrice, Mwamba Miaka, Erick, Boelaert, Marleen, Lehane, Mike, Torr, Steve and Stanton, Michelle (2020) 'Impact of tiny targets on Glossina fuscipes quanzensis, the primary vector of human African trypanosomiasis in the Democratic Republic of the Congo'. PLoS Neglected Tropical Diseases, Vol 14, Issue 10, e0008270.

     Trypanosoma brucei colonizes the tsetse gut via an immature peritrophic matrix in the proventriculus.

    Rose C, Casas-Sánchez A, Dyer NA, Solórzano C, Beckett AJ, Middlehurst B, Marcello M, Haines LR, Lisack J, Engstler M, Lehane MJ, Prior IA, Acosta-Serrano Á. Nat Microbiol. 2020 Jul;5(7):909-916. doi: 10.1038/s41564-020-0707-z. Epub 2020 Apr 20. PMID: 32313202

    Tsetse salivary glycoproteins are modified with paucimannosidic N-glycans, are recognised by C-type lectins and bind to trypanosomes.

    Kozak RP, Mondragon-Shem K, Williams C, Rose C, Perally S, Caljon G, Van Den Abbeele J, Wongtrakul-Kish K, Gardner RA, Spencer D, Lehane MJ, Acosta-Serrano Á. PLoS Negl Trop Dis. 2021 Feb 2;15(2):e0009071. doi: 10.1371/journal.pntd.0009071. eCollection 2021 Feb.

    Scaling up of tsetse control to eliminate Gambian sleeping sickness in northern UgandaHope, Andrew, Mugenyi, Albert, Esterhuizen, Johan, Tirados, Inaki, Cunningham, Lucas, Garrod, Gala, Lehane, Mike, Longbottom, Joshua, Mangwiro, TN Clement, Opiyo, Mercy, Stanton, Michelle, Torr, Steve, Vale, Glyn A., Waiswa, Charles and Selby, Richard (2022) 'Scaling up of tsetse control to eliminate Gambian sleeping sickness in northern Uganda'. PLoS Neglected Tropical Diseases, Vol 16, Issue 6, e0010222.

    Estimating the impact of Tiny Targets in reducing the incidence of Gambian sleeping sickness in the North-west Uganda focus  Bessell, Paul R., Esterhuizen, Johan, Lehane, Mike, Longbottom, Joshua, Mugenyi, Albert, Selby, Richard, Tirados, Inaki, Torr, Steve, Waiswa, Charles, Wamboga, Charles and Hope, Andrew (2021) 'Estimating the impact of Tiny Targets in reducing the incidence of Gambian sleeping sickness in the North-west Uganda focus'. Parasites & Vectors, Vol 14, Issue 410.