Systems Vaccinology: Its promise and challenge for vaccine design
Speaker: Dr Helder Nakaya. Assistant Professor at the University of São Paulo (Brazil) and Adjunct Professor at Emory University School of Medicine (USA).
Systems vaccinology has recently emerged as an interdisciplinary field that combines systems-wide measurements, networks and predictive modeling in the context of vaccinology. With the technological revolutions that occurred in the past decades, we are now able to access and integrate information about all the components within a biological system (e.g., genes, proteins, cells) and use it to compute and predict that system's behavior. When applied to vaccinology, systems biology approaches can help us to understand the mechanisms by which vaccines stimulate protective immunity, and also to identify predictors of vaccine-induced immunity. This seminar highlights how systems vaccinology has led to the discovery of certain signatures that can predict the immunogenicity of influenza and yellow fever vaccines, and how its application towards basic immunology research may provide novel mechanistic insights about immune regulation.
Helder Nakaya’s lab is focused on investigating the basis of infectious diseases using computational systems biology. With a PhD in Molecular Biology and extensive training in Bioinformatics, he became an expert in Systems Vaccinology, an interdisciplinary field that combines systems-wide measurements, networks, and predictive modeling in the context of vaccines and infectious disease. Dr. Nakaya has developed systems biology approaches to understand and predict the mechanisms of vaccine induced-immunity for Yellow Fever, seasonal Influenza, Meningococcal, and Tularemia vaccines. Dr Nakaya’s has published his work in front line journals such as Nature Immunology, Immunity, Nature, PNAS, Science.