Ben obtained completed his MBChB in 2005 (University of Manchester) and completed training to become a consultant in Critical Care Medicine and Anaesthesia in March 2016. Ben joined LSTM in 2013 as a clinical research fellow working with the Respiratory Infection Group mid-way through clinical training and completed his MD (University of Liverpool) in November 2016. He continues his affiliation with LSTM, currently working as an honorary research fellow.
Innate immune response in sepsis and septic shock
We want to understand how neutrophil function is affected in patients with severe infection. Neutrophils are the most abundant immune cell in humans and act as the first line of defence against a wide range of infections. We have developed a ‘near-patient’ flow cytometric test to measure neutrophil function. Our aim is to validate this assay in severely unwell patients to stratify clinical management and potentially guide future immunomodulatory therapies.
We are investigating P4 peptide as a potential immunostimulatory therapy for patients with severe infection. P4 peptide is fragment of the naturally occurring protein, pneumococcal surface antigen A (PsaA), found to augment bacterial uptake and killing by phagocytic cells. We are currently engaged in a developmental programme to generate pre-clinical data to support an application for first in human studies.
Clinical response to influenza infection
Influenza, and particularly pandemic influenza present a major challenge to safe and effective healthcare delivery internationally. We are investigating proposed triage pathways and guidelines for patients who present to hospital with influenza to determine their utility and develop pragmatic alternatives that may be used in resource limited settings.
Anaesthetic airway management
Safe airway management is an essential component of patient resuscitation and this is core skill of any anaesthetist and critical care medicine doctor. However, some patients have complex problems that can impact on the ability of doctors to manage their airway. This can lead to life threatening sequelae. We are examining educational models and management techniques for clinicians to perform effectively in the event of such airway difficulty.
PhD supervisor to Mohmad Alsabani, Department of Clinical Infection, Microbiology and Immunology, University Liverpool
- Fellow of the Royal College of Anaesthetists (FRCA)
- Fellow of the Faculty of Intensive Care Medicine (FFICM)