Dr Elena Mitsi

Post-Doctoral Research Associate

Areas of interest

Microbiological detection and analysis as part of the Experimental Human Pneumococcal Carriage, Interaction of potential respiratory pathogens in the nasopharynx, Effect of P4 peptide in neutrophils and monocytes acquired from critically ill patient with Sepsis, Alveolar Macrophages function and pneumococcal susceptibility. 

Background 

Elena obtained a BSc (Hons) in Molecular Biology from the University of Patras (Greece) in 2005, following an MRes in Biotechnology from the same University (2005-2008). She was awarded a 2 years Research Fellowship sponsored by the Hellenic Institute of Research and Technology as part of the MRes. In 2019, she obtained a PhD in Immunology from Liverpool School of Tropical Medicine.

Research

From 2008 to 2010 Elena worked as a Research Scientist in Prof. John Vlachogiannis group at the University Hospital of Patras (Greece), investigating growth factors and apoptosis-related protein expression in several human kidney diseases. From 2010 to 2013 she worked as microbiologist at the Microbiology Institute of Patras.

In 2013, she joined the Respiratory Infection Group in September 2013 as Senior Research Assistant. She worked on both microbiological and immunological aspects of the Experimental Human Pneumococcal Carriage model in Respiratory Clinical Research team. After the completion of her PhD studies, she progressed to the Post-Doctoral Research Associate.

Her research focuses on mucosal immunology to infectious diseases, in particular lung immunity against bacterial pathogens, such as S. pneumoniae, and viral respiratory infection (influenza, RSV, SARS-CoV-2).

Teaching

During her MSc (2005 - 2008) she was teaching undergraduate students PCR and ELISA techniques in Molecular Biology practical courses. Since 2013 she has been teaching the laboratory session on pneumonia and respiratory health for the MSc Tropical Infectious Diseases course at LSTM.

Current Projects

SARS-CoV-2 and S. pneumoniae interactions during COVID-19 disease- Pfizer granted to Dr Elena Mitsi & Prof Daniela Ferreira

Impact of pneumococcal colonisation and of Live Attenuated and Inactivated virus in the human lung- Bill and Melinda Gates Foundation to Dr Elena Mitsi & Prof Daniela Ferreira

Effect vaccines on Experimental Human Pneumococcal Carriage – Bill and Melinda Gates Foundation grant to Dr. Daniela Ferreira.

Selected publications

  • "Mitsi, E., B. Carniel, J. Reine, J. Rylance, S. Zaidi, A. Soares-Schanoski, V. Connor, A. M. Collins, A. Schlitzer, E. Nikolaou, C. Solorzano, S. Pojar, K. C. Jambo, M. R. Oggioni, M. De Ste Croix, S. B. Gordon, S. P. Jochems & D. M. Ferreira (2019) Nasal Pneumococcal Density is Associated with Microaspiration and Heightened Human Alveolar Macrophage Responsiveness to Bacterial Pathogens. Am J Respir Crit Care Med.

    Mitsi, E., A. M. Roche, J. Reine, T. Zangari, J. T. Owugha, S. H. Pennington, J. F. Gritzfeld, A. D. Wright, A. M. Collins, S. van Selm, M. I. de Jonge, S. B. Gordon, J. N. Weiser and D. M. Ferreira (2017). Agglutination by anti-capsular polysaccharide antibody is associated with protection against experimental human pneumococcal carriage. Mucosal Immunol 10(2): 385-39

    Jochems S.P., Marcon F, Carniel B, Holloway M, Mitsi E, Smith E, Gritzfeld J, Solórzano C, Reiné R, Pojar S, Nakaya H, Ferreira DM. Inflammation induced by influenza virus impairs innate control of human pneumococcal carriage. Nat Immunol 19(12): 1299-1308

    Mitsi E, Kamng’ona R, Rylance J, Reiné J, Solórzano CD, Mwandumba HC, Ferreira DM,Jambo KC. Human alveolar macrophages phenotype in steady state has a combined M1 and M2 signature independent of environmental exposures. Respir Res 2018; 19: 66.

    *Mitsi, E, Morton, B., S. H. Pennington, J. Reine, A. D. Wright, R. Parker, I. D. Welters, J. D. Blakey, G. Rajam, E. W. Ades, D. M. Ferreira, D. Wang, A. Kadioglu and S. B. Gordon (2016). Augmented Passive Immunotherapy with P4 Peptide Improves Phagocyte Activity in Severe Sepsis. Shock 46(6): 635-641. "