Dr Nicholas Feasey

Reader

Having completed clinical training at the Royal Free, Nick Feasey specialized in Clinical Infectious Diseases and Medical Microbiology, firstly at St George’s London and subsequently spending three years in Malawi at the Malawi Liverpool Wellcome Trust Clinical Research Programme (MLW) and then a year at the Wellcome Trust Sanger Institute (WTSI). His research in Malawi focused on causes of and outcomes from bloodstream infection (BSI), especially invasive Salmonella disease. The work demonstrated a fall in BSI of all causes following the roll-out of antiretroviral therapy, especially recurrent Salmonella BSI. Investigation of the genomic epidemiology of Salmonella Enteritidis at WTSI revealed the existence of two novel clades of Enteritidis circulating in Africa. He moved to the Liverpool School of Tropical Medicine in 2013 as Senior Lecturer, with a remit to expand tropical bacteriology research. He holds an appointment as Honorary Consultant at the Royal Liverpool University Hospital.

 

Teaching

Lectures on the Liverpool DTMH and leads the non-malaria febrile illness week.

Currently supervising 4 PhD students. 

 

Research 

Current projects include understanding the causes of fever and severe sepsis in Malawi, establishing the reservoirs of Salmonella Typhi and investigating the transmission of antimicrobial resistant Enterobacteriaceae using genomics and transmission modelling in collaboration with WTSI, PHE and CHICAS, Lancaster. Previous work has been published in major journals including Nature Genetics, The Lancet and Lancet Infectious Diseases.

 

Other relevant expertise, professional memberships.

  • Member: Wellcome Trust Surveillance and Epidemiology of Drug-Resistant Infections Consortium (SEDRIC)
  • Member: UK Department of Health Technical Advisory Group: The Fleming Fund
  • Guest Editor: PLOS NTDs 

 

Publications

  • Selected Publications

    Rothe CR, Sloan D, Goodson P, Chikafa J, Mukaka M, Denis B, Harrison T, van Oosterhout JJ, Heyderman RS, Lalloo DG, Allain T, Feasey N A prospective longitudinal study of the clinical outcomes from cryptococcal meningitis following treatment induction with 800mg oral fluconazole in Blantyre, Malawi PLOS1 (in press)

    Feasey N, Banada P, Howson W, Sloan SJ, Heyderman R, Boehme C, Allain RS, Allain T, Chipungu G, Corbett EL, Alland D. Validation of GeneXpert for diagnosis of tuberculosis from blood confirms mycobacteraemia as a poor prognostic marker J Clin Microbiol. 2013 Jul;51(7):2311-6. doi: 10.1128/JCM.00330-13. Epub 2013 May 15

    Katangwe T, Purcell J, Bar-Zeev N, Denis B, Montgomery JL, Dance D, Feasey N*, Moxon CA* The first case of human meliodosis in East Africa EID 2013 Jun;19(6):981-4. doi: 10.3201/eid1906.120717

    Feasey N, Dougan G, Kingsley RA, Heyderman RS, Gordon MA. Invasive Nontyphoidal Salmonella: an emerging and neglected tropical disease in Africa. Lancet 2012 Jun 23;379(9834):2352-63

    Okoro C, Kingsley RA, Quail MA, Kankwatira AM, Feasey N, Parkhill J, Dougan G, Gordon MA. High-resolution single nucleotide polymorphism analysis distinguishes recrudescence and re-infection in recurrent invasive non-typhoidal Salmonella Typhimurium disease. Clin Infect Dis 2012 Apr;54(7):955-63